Asymmetric Synthesis of <i>N</i> ‐Fmoc‐( <i>S</i> )‐7‐aza‐tryptophan via Alkylation of Chiral Nucleophilic Glycine Equivalent
نویسندگان
چکیده
An efficient method for the synthesis of (S)-7-aza-tryptophan via tridentate chiral auxiliary derived Ni(II)-complexes has been developed. This three-step includes alkylation, disassembling and Fmoc-protection. The desired Fmoc-L-7-AzaTrp-OH was obtained in over 49 % yield with excellent diastereoselectivity.
منابع مشابه
Nucleophilic chiral amines as catalysts in asymmetric synthesis.
2.1. Kinetic Resolution of Alcohols and Amines 2987 2.2. Ketene Acylation 2995 2.3. Cycloadditions 2996 2.3.1. â-Lactone Formation 2996 2.3.2. â-Lactam Formation 2997 2.3.3. Ketene Dimerization 2999 2.4. Halogenation 3000 2.5. Baylis−Hillman Reactions 3000 2.6. Desymmetrization of Cyclic Anhydrides 3002 2.7. C-Acylation 3004 2.8. Cyanation 3004 3. Solid Phase Chemistry 3007 3.1. Solution Cataly...
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2021
ISSN: ['1434-193X', '1099-0690']
DOI: https://doi.org/10.1002/ejoc.202100485